The base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. If the role is non-exempt, overtime pay will be provided consistent with applicable laws. In addition to the salary range listed above, total compensation also includes generous equity, performance-related bonus(es) for eligible employees, and the following benefits.

• Medical, dental, and vision insurance for you and your family, with employer contributions to Health Savings Accounts

• Pre-tax accounts for Health FSA, Dependent Care FSA, and commuter expenses (parking and transit)

• 401(k) retirement plan with employer match

• Paid parental leave (up to 24 weeks for birth parents and 20 weeks for non-birthing parents), plus paid medical and caregiver leave (up to 8 weeks)

• Paid time off: flexible PTO for exempt employees and up to 15 days annually for non-exempt employees

• 13+ paid company holidays, and multiple paid coordinated company office closures throughout the year for focus and recharge, plus paid sick or safe time (1 hour per 30 hours worked, or more, as required by applicable state or local law)

• Mental health and wellness support

• Employer-paid basic life and disability coverage

• Annual learning and development stipend to fuel your professional growth

• Daily meals in our offices, and meal delivery credits as eligible

• Relocation support for eligible employees

• Additional taxable fringe benefits, such as charitable donation matching and wellness stipends, may also be provided.

More details about our benefits are available to candidates during the hiring process.

This role is at-will and OpenAI reserves the right to modify base pay and other compensation components at any time based on individual performance, team or company results, or market conditions.

About the team

OpenAI’s Forward Deployed Engineering (FDE) team partners with global pharma and biotech, CROs, and research institutions to deploy production-grade AI systems across the R&D value chain. We operate at the intersection of customer delivery and core platform development, converting early deployments into repeatable system standards and evaluation practices that scale across regulated environments.

About the role

As a Life Sciences FDE Manager, you’ll lead a team of FDEs delivering production AI systems across drug discovery and development workflows. You’ll own delivery outcomes and team leverage while staying hands-on as a player-coach. This includes building and shipping alongside the team, setting technical direction, and maintaining a high bar for production-grade systems in regulated environments.

We measure success through the health and quality of your FDE team, production adoption and measurable workflow impact, the quality of eval-driven feedback delivered back to Product and Research, and the repeatability of deployment patterns across life sciences customers.

This role is based in San Francisco. We use a hybrid work model of 3 days in the office per week. We offer relocation assistance. This role will require travel up to 25%.

In this role you will

• Lead and grow a team of FDEs delivering production AI systems across regulated life sciences environments

• Be accountable for your team’s end-to-end delivery outcomes, balancing scope, speed, robustness, and risk in high-stakes deployments

• Coach and develop engineers through direct feedback, high technical standards, and clear expectations for execution and ownership

• Operate as a player-coach, directly contributing to production systems while leading, coaching, and setting technical direction

• Guide teams through ambiguous, multi-workstream engagements spanning data, workflows, infrastructure, security, and scientific stakeholders

• Run evaluation loops that measure model and system quality against workflow-specific scientific benchmarks, then convert results into crisp roadmap input

You might thrive in this role if you

• Bring 8+ years of engineering or technical delivery experience, including 2+ years managing high-performing customer-facing or systems-oriented engineering teams

• Have led complex, high-pressure technical programs from prototype through sustained production use in regulated environments

• Have experience working in or adjacent to life sciences R&D, clinical research, scientific software, or regulated scientific data environments

• Write and review production-grade code and can guide architectural decisions across backend, data, and ML-adjacent systems

• Translate scientific and technical tradeoffs into clear delivery plans, risk posture, and measurable outcomes across scientific, clinical, technical, and executive audiences

• Elevate team performance through clarity, judgment, and technical credibility

• Turn field experience into precise, actionable feedback for Product, Research, and GTM teams

About OpenAI

OpenAI is an AI research and deployment company dedicated to ensuring that general-purpose artificial intelligence benefits all of humanity. We push the boundaries of the capabilities of AI systems and seek to safely deploy them to the world through our products. AI is an extremely powerful tool that must be created with safety and human needs at its core, and to achieve our mission, we must encompass and value the many different perspectives, voices, and experiences that form the full spectrum of humanity.

We are an equal opportunity employer, and we do not discriminate on the basis of race, religion, color, national origin, sex, sexual orientation, age, veteran status, disability, genetic information, or other applicable legally protected characteristic.

For additional information, please see OpenAI’s Affirmative Action and Equal Employment Opportunity Policy Statement.

Background checks for applicants will be administered in accordance with applicable law, and qualified applicants with arrest or conviction records will be considered for employment consistent with those laws, including the San Francisco Fair Chance Ordinance, the Los Angeles County Fair Chance Ordinance for Employers, and the California Fair Chance Act, for US-based candidates. For unincorporated Los Angeles County workers: we reasonably believe that criminal history may have a direct, adverse and negative relationship with the following job duties, potentially resulting in the withdrawal of a conditional offer of employment: protect computer hardware entrusted to you from theft, loss or damage; return all computer hardware in your possession (including the data contained therein) upon termination of employment or end of assignment; and maintain the confidentiality of proprietary, confidential, and non-public information. In addition, job duties require access to secure and protected information technology systems and related data security obligations.

To notify OpenAI that you believe this job posting is non-compliant, please submit a report through this form. No response will be provided to inquiries unrelated to job posting compliance.

We are committed to providing reasonable accommodations to applicants with disabilities, and requests can be made via this link.

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At OpenAI, we believe artificial intelligence has the potential to help people solve immense global challenges, and we want the upside of AI to be widely shared. Join us in shaping the future of technology.

Compensation Range: $252K - $335K